By the time New York City confirmed its first case of the coronavirus on March 1, 1000’s of infections had been already silently spreading by way of the town, a hidden explosion of a illness that many nonetheless considered as a distant risk as the town awaited the primary indicators of spring.
Hidden outbreaks had been additionally spreading virtually utterly undetected in Boston, San Francisco, Chicago and Seattle, lengthy earlier than testing confirmed that every metropolis had a significant drawback, in response to a mannequin of the unfold of the illness by researchers at Northeastern University who shared their outcomes with The New York Times.
Even in early February — whereas the world centered on China — the virus was not solely more likely to be spreading in a number of American cities, but additionally seeding blooms of an infection elsewhere within the United States, the researchers discovered.
As political leaders grappled in February with the query of whether or not the outbreak would develop into critical sufficient to order measures like faculty closures and distant work, little or no systematic testing for the virus was happening.
“Meanwhile, in the background, you have this silent chain of transmission of thousands of people,” mentioned Alessandro Vespignani, director of the Network Science Institute at Northeastern University in Boston, who led the analysis workforce.
Modeling the unfold of a illness is inherently inexact, involving estimates of how typically individuals are available contact and transmit the virus as they journey, work and socialize. The mannequin estimates all infections, together with these in individuals who might expertise delicate or no symptoms and those that are never detected in testing.
Other disease researchers said the findings of Dr. Vespignani’s team were broadly in line with their own analyses. The research offers the first clear accounting of how far behind the United States was in detecting the virus. And the findings provide a warning of what can recur, the researchers say, if social distancing restrictions are lifted too quickly.
Dr. Robert R. Redfield, the director of the Centers for Disease Control and Prevention, said last week that American health officials had been successful in tracking the first known cases and their contacts in the United States before the outbreak got out of control.
“Through Feb. 27, this country only had 14 cases,” he said during a briefing. “We did that isolation and that contact tracing, and it was very successful. But then, when the virus more exploded, it got beyond the public health capacity.”
But the new estimates of coronavirus infections are vastly higher than those official counts.
By late February, as the world’s attention shifted to a dire outbreak in Italy, those 14 known American cases were a tiny fraction of the thousands of undetected infections that the researchers estimated were spreading from person to person across this country.
And more cases may have been arriving in the United States by the day.
“Knowing the number of flights coming into New York from Italy, it was like watching a horrible train wreck in slow motion,” said Adriana Heguy, director of the Genome Technology Center at New York University’s Grossman School of Medicine.
Dr. Heguy’s team and another at the Icahn School of Medicine at Mount Sinai have found through genetic analysis that the seeds of most infections in New York came from multiple locations in Europe, rather than directly from China.
“We weren’t testing, and if you’re not testing you don’t know,” Dr. Heguy said. The new estimates suggesting that thousands of infections were spreading silently in the first months of the year “don’t seem surprising at all,” she said.
There are other signs that the outbreak was worse at an earlier point than previously known. This week, health officials in Santa Clara County, Calif., announced a newly discovered coronavirus-linked death on Feb. 6, weeks earlier than what had been previously thought to be the first death caused by the virus in the United States.
Some scientists cautioned that the new report’s estimates of an enormous, unseen wave of infections could be too high — even though testing surveillance lagged at the time.
“Even with these corrections, it’s still on the high side — this is higher than I would have expected,” said Dr. Donald Burke, a professor of epidemiology at the University of Pittsburgh Graduate School of Public Health.
Others said that the findings were in line with the fragmentary evidence that had been available until now. Lauren Ancel Meyers, a professor of biology and statistics at the University of Texas at Austin, said that her own risk estimates and most recent projections reveal a grim stealthiness of early coronavirus spread.
“By the time you see a few cases, it’s pretty certain that you already have an outbreak underway,” Dr. Meyers said.
Dr. Vespignani’s approach models the outbreak over time based on what is known about the virus and where it has been detected. It estimates the spread of the disease by simulating the movements of individual people based on where people fly, how they move around, when they go to school and other data. By running the model under various conditions — when schools are closed, say — his team estimates where the virus may have spread undetected.
Unseen carriers of the disease, many of them with mild symptoms or none at all, can still spread the virus. For that reason, by the time leaders in many cities and states took action, it was already too late to slow the initial spread.
A few cities with early outbreaks, notably Seattle, are believed to have avoided enormous growth later by heeding the models available at the time and taking action well ahead of the rest of the country.
“We knew the numbers we saw were just the tip of the iceberg, and that there were much greater numbers below the surface,” Jenny A. Durkan, the mayor of Seattle, said in an interview. “We had to act.”
“Even while we learn new things about this virus almost daily, one thing remains consistent: New Yorkers were put at risk by the federal government’s total failure to provide us with adequate testing capability,” said the mayor’s press secretary, Freddi Goldstein.
In mid-February, a month before New York City schools were closed, New York City and San Francisco already had more than 600 people with unidentified infections, and Seattle, Chicago and Boston already had more than 100 people, the findings estimate. By March 1, as New York confirmed its first case, the numbers there may already have surpassed 10,000.
From these primary travel hubs and a few other cities, the model shows, the disease was then spread to other locations in the United States.
Dr. Vespignani said he and his research team warned officials of the silent spread, posting some of their early projections in mid-February. “We were talking to officials here, and it was the same reaction we got in Italy, in the U.K., in Spain,” Dr. Vespignani said. “They told me, ‘OK, that’s happening on your computer, not in reality.’ Look,” he added, “No one’s going to shut down a country based on a model.”
The virus moved under the radar swiftly in February and March, doctors and researchers said, because few cities or states had adequate surveillance systems in place. And testing, if it was being done at all, was haphazard. Emergency rooms were busy preparing for the predicted onslaught and likely missed some early virus-related deaths, and did not have the time or tools to verify infections on the fly, experts said.
It was mid-March before teams at N.Y.U. and Mount Sinai began taking samples for testing in New York. On Thursday, Gov. Andrew M. Cuomo announced results from antibody testing of grocery store shoppers— which researchers warned were preliminary and could change — that suggests one of every five New Yorkers may have been infected.
The new findings from the model produce a range of possible outcomes for when the virus may have infected 10 people in each city. In New York, for example, the model shows that the first 10 infected people could have been walking the streets of the city as early as the last week in January, or as late as the middle of February. From there, the infections in the centers of the outbreak grew exponentially.
Trevor Bedford, an associate professor at the Fred Hutchinson Cancer Research Center and the University of Washington in Seattle, said it became clear in late February that “community transmission” — an infectious outbreak — was probably silently underway in Washington after a single test result came back positive for someone who had no symptoms.
Whatever the precise scale of the initial outbreak, that same dynamic will accelerate once measures to mitigate the spread are relaxed without other public health measures in place, Dr. Burke said. “When you take away social distancing, everything will go right through the roof,” he said.
Get more stuff like this
Subscribe to our mailing list and get interesting stuff and updates to your email inbox.
Thank you for subscribing.
Something went wrong.